. Atopic allergy is a hypersensitive immunological condition mediated by IgE. Lymphocyte B cells stimulated by a specific allergen
produce IgE to the antigen. The IgE antibodies bind to the receptors on the surface of mast cells or basophilic leukocytes which triggers cell degranulation and the release of vasoactive amines, causing smooth muscle contraction, itching, swelling and transmucosal leakage of extracellular fluids.
. The most common clinical manifestations of this process are hay fever, asthma, dermatitis, hives and anaphylactic shock.
. The evaluation of IgE level in patient serum for various allergens is valuable in the diagnosis and treatment of atopic allergy.
. PROTIAT Allergy-Q 44 Atopy panel is an in vitro diagnostic test used for the quantitative determination of allergen-specific specific IgE concentrations in human serum, using immunoblotting technique.
. It utilizes 44 types of food allergens together with Total IgE under one test.