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19001717 . Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder that affects the function of red blood cells. It is caused by mutations in the G6PD gene, leading to reduced or absent activity of the G6PD enzyme, which plays a crucial role in protecting red blood cells from oxidative damage.
. When exposed to certain triggers such as infections, certain medications (e.g., sulfa drugs, antimalarials), or fava beans, affected individuals may develop hemolytic anemia, a condition where red blood cells break down prematurely, causing symptoms like jaundice, fatigue, dark urine, and shortness of breath.
. G6PD deficiency is X-linked, meaning it primarily affects males, while females can be carriers or mildly affected.
