Schistosoma is a parasitic worm that causes the worrisome disease schistosomiasis. Upon entering the body, it triggers an immune response that produces specific antibodies, including IgG. The Schistosoma IgG test is a valuable tool for detecting antibodies against Schistosoma, thus diagnosing schistosomiasis. Not only is it an effective screening test, but it also provides important information for assessing the infection status and monitoring treatment effectiveness. However, the test results need to be carefully analyzed, combined with clinical factors and exposure history to reach the most accurate diagnosis. A negative result does not completely rule out the possibility of Schistosoma infection and needs to be reassessed in the specific context of each individual.