ROTEM-INTEM**

Detection of Trisomies 21, 18, 13, Sex Chromosomes Aneuploidies (XO, XXX, XXY, XYY), Other Autosomes Aneuploidies, and Microdeletions/Microduplications (92 types).

Non-Invasive Prenatal Testing (NIPT) is a screening test based on cell-free DNA fragments derived from the placenta, NOT a diagnostic test.

This test package is only performed for SINGLE PREGNANCY. The NIPT result is valid only for the specific sample submitted and must be interpreted by qualified professionals within the clinical context.

Tests Supporting Early Diagnosis and Monitoring of Liver Cirrhosis Progression

The concentration of M2BPGi in serum varies significantly among different liver diseases, and studies have shown it to be a marker of liver fibrosis in chronic hepatitis B. M2BPGi values have demonstrated high diagnostic accuracy for progressive liver fibrosis, with a negative predictive value above 95%.

M2BPGi Reflects the Stages of Liver Cirrhosis Progression

A low C.O.I. (Cut-Off Index) is found in healthy individuals and increases significantly with the progression of cirrhosis. The results of M2BPGi (C.O.I.) measurement at various stages of cirrhosis (from healthy individuals to stages F0 to F4) show this trend:

Healthy individuals: < F0 Chronic hepatitis: F1 – F3 (C.O.I: 3 → 5) Cirrhosis: F4 (C.O.I: 5 → >15)

An interleukin-10 (IL-10) test measures the level of IL-10 in a blood sample. It can be used to help understand the cause of immune, inflammatory, allergic, or infectious disorders.