. The Risk of Ovarian Malignancy Algorithm (ROMA), a calculation developed from CA 125 (Cancer Antigen 125) & HE 4 (Human epididymis protein 4) values alongside the menopausal status, is an aid in estimating the risk of having epithelial ovarian cancer in patients presenting with an adnexal mass who will undergo surgical intervention.
. ROMA is most effective when used alongside clinical evaluation and imaging techniques (e.g., ultrasound) to improve diagnostic accuracy for ovarian cancer.