Pepsinogen I + II

. Pepsinogens are inactive precursors of pepsin, proteolytic enzymes present in gastric juice, and are immunologically classified into pepsinogen I (PG I) and pepsinogen II (PG II).
. Pepsinogen I: Secreted by the chief cells and mucous neck cells in the fundus and corpus of the stomach. Low levels of Pepsinogen I may indicate atrophic gastritis, particularly in the corpus of the stomach.
. Pepsinogen II: Secreted by the cells throughout the stomach and proximal duodenum. Elevated levels may suggest gastric inflammation or more extensive gastric mucosal damage.
. Pepsinogen I/II Ratio: This ratio is a marker for atrophic gastritis. A low Pepsinogen I/II ratio (<3) may indicate atrophic gastritis or gastric mucosal atrophy. A high ratio is typically seen in normal gastric function. . This test is valuable in screening for precancerous gastric conditions, monitoring patients at risk of gastric cancer, and differentiating between types of gastritis.

  • Others

Patient Instructions:
. Fast for 10-12 hours before collection.
. If possible, discontinue antacids or other medications affecting stomach acidity (e.g., proton pump inhibitors (PPIs), H2 blockers) or gastrointestinal motility, for at least 48 hours before collection.
Sample Type:
Serum
Result Time:

After 2 hours 30 minutes
After cutoff: 9:00 AM next day

Storage & Transportation:
-
Cutoff Times:

9:30 PM Monday – Saturday
8:30 PM Sunday

30 minutes required for samples arrived at Cao Thang till receive by Laboratory

Biomakers
  • 1. Pepsinogen I [Serum]
  • 2. Pepsinogen II
  • 3. Pepsinogen I / Pepsinogen II Ratio

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