M2BPGi(Mac-2 Binding Protein glycosylation isomer) **

Tests Supporting Early Diagnosis and Monitoring of Liver Cirrhosis Progression

The concentration of M2BPGi in serum varies significantly among different liver diseases, and studies have shown it to be a marker of liver fibrosis in chronic hepatitis B. M2BPGi values have demonstrated high diagnostic accuracy for progressive liver fibrosis, with a negative predictive value above 95%.

M2BPGi Reflects the Stages of Liver Cirrhosis Progression

A low C.O.I. (Cut-Off Index) is found in healthy individuals and increases significantly with the progression of cirrhosis. The results of M2BPGi (C.O.I.) measurement at various stages of cirrhosis (from healthy individuals to stages F0 to F4) show this trend:

Healthy individuals: < F0 Chronic hepatitis: F1 – F3 (C.O.I: 3 → 5) Cirrhosis: F4 (C.O.I: 5 → >15)