Histopathological examination and diagnosis biopsy (<0.5cm) are indicated for specimens smaller than 0.5 cm, obtained from patients during procedures such as endoscopy, biopsy by clinicians. Specimens include biopsy of small cervical leukoplakia, gastrointestinal polyps, gastric and colorectal cancers, etc. The specimens are preserved in 10 % neutral buffered formalin and sent to the Histopathology laboratory. In the laboratory, pathologists process and analyze the samples under a light microscope to provide accurate, specific, and comprehensive diagnoses, including: (1) Cancer or non-cancer disease (2) Histological type (3) Histological grade (4) Invasion status (5) Metastasis status (6) Surgical margin status (7) Stage of cancer Histopathological tests are the gold standard and are crucial before, during, and after treatment many types of disease related to variety of clinical specialties, including surgery, internal medicine, dermatology, neurology, radiotherapy, chemotherapy, and oncology. Based on these results, clinicians can establish optimal personalized treatment plans, management strategies, follow-up schedules, and prognoses tailored to each patient.