The ENA-6 Profile test is used to detect specific autoantibodies directed against extractable nuclear antigens (ENAs) associated with systemic autoimmune connective tissue diseases. This panel includes antibodies against SSA (Ro), SSB (La), U1-snRNP (RNP68/70 kDa), Sm, Scl-70, and Jo-1. Identifying these autoantibodies supports the diagnosis and differentiation of conditions such as systemic lupus erythematosus (SLE), Sjögren’s syndrome, mixed connective-tissue disease (MCTD), systemic sclerosis (Scleroderma), and idiopathic inflammatory myopathies.




