Anti-CCP are autoantibodies your immune system produces. Autoantibodies can cause disease by attacking the body's healthy cells by mistake. Anti-CCP attacks healthy tissues in the joints, which can cause pain, swelling, and stiffness. If CCP antibodies are present in your blood, it can be a sign of rheumatoid arthritis. Anti-CCP and another test, called an RF test, are usually done to diagnose rheumatoid arthritis.