An "ANCA IF/Kidney confirmation (ANCA+MPO/PR3) test" is a blood test used to diagnose potential kidney involvement in an autoimmune condition called ANCA-associated vasculitis, by checking for the presence of antineutrophil cytoplasmic antibodies (ANCA) specifically targeting myeloperoxidase (MPO) or proteinase 3 (PR3) antigens, often with a confirmation step using indirect immunofluorescence microscopy to visualize the staining pattern on neutrophils in the blood sample; a positive result, particularly with a characteristic staining pattern, can indicate kidney damage due to vasculitis.