Choose Diag’s NIPT - Your Baby’s Health, Your Peace of Mind

Screen for 100+ chromosomal abnormalities like Down, Edwards, Patau syndromes & more
Highly accurate - up to 99.9%
100% safe for both mother and fetus
Early testing - from the 10th week
Fast results - after 7 days
Non-invasive, quick and painless

NIPT (Non-Invasive Prenatal Testing) is a highly accurate screening test that analyzes cell-free fetal DNA (cff-DNA) derived from the placenta and circulating in the maternal blood to assess the risk of certain chromosomal abnormalities in the fetus.

This method is highly recommended by medical experts for its effectiveness in screening chromosomal abnormalities as early as the 10th week of gestation ensuring absolute safety for both the mother and the fetus.

NIPT offers an accuracy rate of up to 99.9%, providing comprehensive screening for over 100 genetic conditions related to chromosomal abnormalities, including aneuploidies and selected microdeletions/microduplications, across all 23 chromosome pairs.

Diag NIPT panels screen for:
- Three common Trisomy syndromes: Trisomy 21 (Down Syndrome), Trisomy 18 (Edwards Syndrome), and Trisomy 13 (Patau Syndrome).
- Four sex chromosome aneuploidies: Turner Syndrome (XO), Triple X Syndrome (XXX), Klinefelter Syndrome (XXY), and Jacob's Syndrome (XYY).
- Other autosomal aneuploidies.
- Microdeletions/Microduplications (92 Types).

Diag NIPT utilizes the DNBSEQ™ sequencing technology, which combines the advantages from low amplification error rates from DNA nanoballs (DNBs) and high-density patterned arrays. These advantages dramatically improve the sequencing accuracy.

NIPT is a screening test, not a diagnostic test. In cases of high-risk NIPT results, post-test genetic counseling is advised, and confirmatory diagnostic testing is recommended.

Pregnant women of any age (especially those aged 35 and above)
Pregnant women at increased risk for chromosomal abnormalities
Pregnant women with a history of recurrent miscarriage, stillbirth, or preterm labor
Pregnant women with a history of fetal delivery with chromosomal abnormalities
Pregnant women with a family history of chromosomal abnormalities
Contraindications for invasive prenatal testing (e.g., threatened abortion, tendency of bleeding, fever, chronic active infection …etc.)
Pregnant women with abnormal ultrasound
Pregnant women with high-risk value in the traditional biochemical-based screening methods (e.g., Double Test, Triple Test)
Pregnant women who have missed the best time for the traditional biochemical-based screening methods (e.g., Double and Triple tests)
Pregnant women working in hazards environments with exposure to chemicals
Pregnant women with singleton or twin pregnancies
Pregnancy following IVF or IUI

Chromosome 13

Trisomy 13, also known as Patau syndrome, happens when there's an extra copy of chromosome 13. This extra chromosome causes severe health issues. People with Patau syndrome may have intellectual disabilities, delays in development, and physical abnormalities such as cleft lip and palate and extra fingers or toes. They also often have heart defects. Many babies with Patau syndrome don't live past the first days or weeks.

Chromosome 18

Trisomy 18, also called Edwards syndrome, occurs when there's an extra copy of chromosome 18. This leads to serious health and development problems. Babies with this condition often have a low birth weight and a small head size. They may also have birth defects in their heart and other organs. Structural anomalies can also include a clenched hand with overlapping fingers, malformed feet, and a small jaw. If the tests show a high chance of Trisomy 18, it's important to talk to a doctor or genetic counselor. They can explain what it means and help you decide what's best for you and your baby.While Trisomy 18 is a serious condition, knowing about it early on can help you make informed decisions and get the support you need during your pregnancy. Unfortunately, these complex health challenges often result in life-threatening complications for many affected infants

Chromosome 21

Trisomy 21, also called Down syndrome, happens when there is an extra third copy of chromosome 21. This extra chromosome changes a person's development both in how they look and learn. People with Down syndrome have distinct facial features, a level of intellectual disability, and learn more slowly. They can also have heart conditions and other health issues. Down syndrome affects about 1 in 700 live births worldwide. The risk is higher for babies born to mothers over 35, but many babies with Down syndrome are born to younger mothers.

Turner syndrome (XO)

Turner syndrome (XO), a rare genetic disorder affecting females, occurs when one of the two X chromosomes is missing or partially missing. This missing genetic material can lead to a variety of physical and developmental challenges, although the severity and specific symptoms can vary significantly among individuals. Common features of Turner syndrome include short stature, which often becomes noticeable by age 5, and underdeveloped ovaries, leading to infertility and the absence of menstrual periods. Other potential health concerns associated with Turner syndrome may include heart defects, kidney problems, hearing loss, and learning difficulties. Despite these challenges, early diagnosis and appropriate medical management can significantly improve the quality of life for individuals with Turner syndrome. Hormone therapy can help address growth and development issues, while other interventions may be necessary to manage specific health concerns. With proper care and support, girls and women with Turner syndrome can lead healthy, fulfilling lives. Advances in medical research and treatment continue to offer hope and improved outcomes for those affected by this condition.

Triple X Syndrome

Triple X syndrome, also known as 47,XXX, happens when a female has an extra X chromosome. Typically, females have two X chromosomes, but in Triple X syndrome, they have three. This extra chromosome often doesn't cause visible symptoms, and many females with this condition might not even know they have it. Some may be taller than average and might face challenges with learning, especially in reading and math. Fertility issues and early menopause are other possible effects, but many with Triple X syndrome lead healthy lives.

Klinefelter Syndrome

Klinefelter syndrome, also referred to as 47, XXY, occurs when a male has an extra X chromosome. Normally, males have one X and one Y chromosome, but in Klinefelter syndrome, they have two Xs and one Y. This extra X chromosome can lead to symptoms that might not always be obvious. Some males with Klinefelter syndrome might have taller stature, less muscle strength, and less facial and body hair. They may also experience challenges with learning and speech. Additionally, the syndrome can affect fertility, often making it difficult for affected individuals to have children naturally. Klinefelter syndrome can be identified through genetic testing.

Jacobs Syndrome

Jacobs Syndrome, also known as 47, XYY, occurs when a male has an extra Y chromosome. Typically, males have one X and one Y chromosome, but in Jacobs Syndrome, they have one X chromosome and two Y chromosomes. This extra Y chromosome usually doesn't cause any obvious symptoms and many males with this condition might not even be aware they have it. Some individuals with Jacobs Syndrome might be taller than average and could face some challenges with speech and learning. It is important to note, most men with this condition lead normal, healthy lives.

chromosomes 1-12, 14-17, 19-20, and 22

When there are issues with chromosomes 1-12, 14-17, 19-20, and 22, it means the body's genetic blueprint isn't quite following the standard layout. Chromosomes carry our genetic information, and when one of them has a glitch, it can affect how the body grows and works. These abnormalities can lead to a variety of health conditions, depending on which chromosome and what part of it is involved. Each chromosome-related condition has its own set of symptoms and impacts on health, ranging from developmental delays to more specific physical health issues. Getting this information early helps parents and healthcare professionals plan for any special care or treatment the baby might need from the moment they're born, aiming to support the best possible health outcomes.

92 microdeletion / microduplication syndromes

The 92 syndromes of gene deletion and duplication commonly impact health, affecting intellectual and behavioral development as well as various organ systems, including the cardiovascular, digestive, and nervous systems. These syndromes are often accompanied by symptoms such as developmental disorders, congenital abnormalities, immune deficiencies, and neurological disorders.

Carrier Screening 10 test

The Carrier Screening 10 test refers to a genetic test that screens for the carrier status of 10 specific genetic conditions, including: 1. Alpha Thalassemia 2. Beta Thalassemia 3. Galactosemia 4. Phenylketonuria (PKU) 5. G6PD Deficiency 6. Citrin Deficiency 7. Steroid 5-alpha-reductase Deficiency 8. Glycogen Storage Disease Type II (Pompe) 9. Wilson Disease 10. Fabry Disease This test allows the individuals to understand their risk of passing on these conditions to their children if they are carriers, usually done before or during pregnancy. The test can be done for husband and wife. No ultrasound needed to carry out the test.

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Frequently Asked Questions

1. What special cases require NIPT?

Expectant mothers who have undergone a blood transfusion or organ transplant - NIPT can be performed at least 4 weeks after the procedure to ensure accurate results.

Pregnancies affted by Vanishing Twin Syndrome - NIPT can be used if both of the following conditions are met:
(1)The vanishing twin phenomenon occurred 8 weeks of pregnancy or earlier.
(2)There is a gap of at least 8 weeks between the vanishing twin event and the NIPT test.

2. When is NIPT not recommended?

If you are in cases where invasive prenatal screening is contraindicated, you should not do the NIPT test, including threatened abortion, tendency of bleeding, fever, chronic active infection, etc.

3. Amniocentesis or NIPT: Which is an ideal option?

Experts recommend pregnant women undergo NIPT. However, mothers should consider 4 following factors:

- 100% safe: NIPT is asbolutely safe for both the mother and the fetus. Unlike amniocentesis, NIPT does not pose risks such as miscarriage, stillbirth, preterm birth, vaginal bleeding, or infection.

- Highly accurate: NIPT has high accuracy up to 99.9% but is only a screening test. However, as it is a screening test, confirmatory diagnosis through amniocentesis is necessary if a high risk of abnormalities is detected.

- Fast results: NIPT results are available within 5 working days, whereas amniocentesis takes 10 to 14 days.

- Cost-effective: Diag’s NIPT Panels range from 1,500,000 to 7,500,000 VND, whereas amniocentesis costs 10,000,000 VND or more.

4. What fetal abnormalities do the NIPT tests detect?

NIPT helps identify the majority of congenital abnormalities, including:

- Trisomies: Down syndrome (Trisomy 21), Edwards syndrome (Trisomy 18), Patau syndrome (Trisomy 13), Trisomy 22, Trisomy 16, Trisomy 9.

- Sex chromosome aneuploidies: Klinefelter syndrome (XXY), Turner syndrome (Monosomy X), Jacobs syndrome (XYY), Triple X syndrome.

- Deletion/Duplication syndromes: Prader-Willi/Angelman syndrome, DiGeorge syndrome, Jacobsen syndrome, Cat Eye syndrome, Cri-du-chat syndrome, etc.

5. Could low-risk NIPT results bring up any concerns?

A "negative" or "no abnormality detected" result indicates a very low risk of the fetus having genetic disorders. However, low risk does not guarantee the fetus will be free of congenital disorders. Therefore, regular prenatal check-ups and tests as directed by obstetricians are necessary.

6. What should be prepared before taking the NIPT test?

Pregnant women need to bring their most recent ultrasound results to Diag for consultation before the test. There are no specific timing requirements for NIPT.

7. Can I opt for a Double Test or Triple Test instead of NIPT?

Double Test and Triple Test are suitable alternatives in case NIPT is not required or affordable. Diag offers fetal defect screening services at the following prices:

- Double Test: 384,000 VND

- Triple Test: 450,000 VND

8. What is WGS technology in NIPT?

Whole Genome Sequencing (WGS) is the technology used to analyze the entire cell‐free fetal DNA (cffDNA) present in the mother's blood. This method allows the detection of a wide range of genetic abnormalities, from major chromosomal abnormalities (such as trisomies) to smaller variations like deletions and duplications.

WGS utilizes the fetal fraction DNA enrichment process (FF%) to increase the concentration of cffDNA. It combines selective DNA fragment processing with advanced bioinformatics analysis and cutting-edge DNBSEQ™ technology. This process significantly reduces repeat testing rates, minimizes errors and enhances the detection of complex genetic variations, such as those seen in DiGeorge syndrome.

9. How early in pregnancy can I take the NIPT test?

The NIPT test can be performed as early as the 10th week of pregnancy, allowing for early detection of potential chromosomal abnormalities.

10. What happens if my NIPT results indicate a high risk?

If your NIPT results indicate a high risk of chromosomal abnormalities, obstetricians will discuss further diagnostic options, such as amniocentesis to confirm the results.

11. How does NIPT work?

NIPT works by analyzing cell-free fetal DNA found in the mother's blood. This DNA is screened for chromosomal abnormalities that can indicate genetic disorders.

12. Why should I choose the NIPT Pro?

The DIAG's NIPT Pro is optimized to offer the most cost-effective solution. It provides a comprehensive screening for more than 100 congenital abnormalities, surpassing other prenatal screening methods such as Double Test, Triple Test, and older NIPT technologies.

By combining advanced Whole Genome Sequencing (WGS) and DNBSEQ™ technology, NIPT Pro ensures higher accuracy, better detection rates and reduced the need for repeat testing, making it a superior choice for early and safe prenatal screening.

13. How long does it take to get NIPT test results at DIAG?

If DIAG's lab receives the sample before 10:00 AM (Mon & Thu), test results will be available by 10:00 AM four days later.
If DIAG's lab receives the sample after 10:00 AM (Mon - Thu), test results will be available by 10:00 AM seven days later.

Choose Diag’s NIPT - Your Baby’s Health, Your Peace of Mind